My dog Jasper was typically anxious and also had premature arthritis. Because of that, my Vet had him on opioids. Those heavy duty drugs worked, but I wanted to find a better solution. Over a three month period I gradually weaned him completely off the opioids by giving him 3 Advanced Formula Maple Bacon Canna-Biscuits each morning and afternoon. He now no longer takes the opioids, and his anxiety and artritic discomfort continue to be greatly reduced!!