Diesel, my 10 month old, 110 lb rottweiler. He has severe separation anxiety. I have tried calming pills, oils, air fresheners, thunder shirt, various toys, leaving the TV on, leaving my used clothes out and whether we are gone 20 min or two hours, he becomes upset. We bought the Advanced Max and at first I gave him one in the AM and it seemed to help for a bit but he still struggled. We then gave him two in the AM and it helped. He did find a favorite leather boot he keeps taking but I am okay with him keeping that if that is all he chews. So I am placing another order today as I do feel these are not calming him down and making my life so much more pleasant!