Our 10 year Tibetan Mastiff name is Gryphon. Gryphon has cushings disease and severe arthritis, due to the medication he is on we could not give him any pain relief meds, so on the advice of Tibetan Mastiff rescue we started him on Canna-Pet capsules. Wow, what a difference, we have our boy back, its like having a 3 year old dog. He runs and plays now instead of laying around, so I know its helping his arthritis and our vet has had us cut his cushings meds in half. This really does work.