Also known as the hepatic first pass effect – any product absorbed from the gastrointestinal tract is first delivered to the liver by the portal vein. A fraction of the product can be metabolized in the gastrointestinal tract or liver before it even reaches the systemic circulation. Therefore the oral bioavailability of the compounds and terpenes are reduced.
CBD undergoes a substantial first pass effect as your pet digests hemp. The GI tract and liver break down the CBD to metabolites, most notably 7-hydroxy-CBD and CBD-7-oic acid.
The results of this study show that CBD is barely absorbed after oral administration to dogs. This low bioavailability may be due to a first pass effect.
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